Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples

Sensitive detection methods are key to identify secondary EGFR c.2369C>T p.(Thr790Met) in non-small cell lung cancer tissue samples

Abstract Background Correct identification of the EGFR c.2369C>T p.(Thr790Met) variant is key to decide on a targeted therapeutic strategy for patients with acquired EGFR TKI resistance in non-small cell lung cancer. The aim of this study was to evaluate the correct detection of this variant in 1...

Full description

Bibliographic Details
Main Authors: Cleo Keppens, Elisabeth M. C. Dequeker, Etienne Rouleau, Nils ’t Hart, Lukas Bubendorf, Kelly Dufraing, Céline Garrec, Paul Guéguen, Aude Lamy, Antonio Marchetti, Patrick Pauwels, Ales Ryska, Véronique Tack, Luigi Tornillo, Kaat Van Casteren, Jan H. von der Thüsen, Karen Zwaenepoel, Birgit Lissenberg-Witte, Erik Thunnissen, Ed Schuuring
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Cancer
Subjects:
Non-small cell lung cancer
External quality assessment
Predictive biomarker
EGFR
c.2369C>T p.(Thr790Met)
Resistance
Online Access:http://link.springer.com/article/10.1186/s12885-020-06831-3

Internet

http://link.springer.com/article/10.1186/s12885-020-06831-3

Similar Items