Increased local concentration of complement C5a contributes to incisional pain in mice

<p>Abstract</p> <p>Background</p> <p>In our previous study, we demonstrated that local injection of complement C5a and C3a produce mechanical and heat hyperalgesia, and that C5a and C3a activate and sensitize cutaneous nociceptors in normal skin, suggesting a contributi...

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Bibliographic Details
Main Authors: Clark David J, Sun Yuan, Kido Kanta, Liang Deyong, Jang Jun H, Brennan Timothy J
Format: Article
Language:English
Published: BMC 2011-07-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/8/1/80