Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface

γ-Secretase is a multi-subunit enzyme whose aberrant activity is associated with Alzheimer’s disease and cancer. While its structure is atomically resolved, γ-secretase localization in the membrane in situ relies mostly on biochemical data. Here, we combined fluorescent tagging of γ-secretase subuni...

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Bibliographic Details
Main Authors: Abril Angélica Escamilla-Ayala, Ragna Sannerud, Magali Mondin, Karin Poersch, Wendy Vermeire, Laura Paparelli, Caroline Berlage, Marcelle Koenig, Lucia Chavez-Gutierrez, Maximilian H Ulbrich, Sebastian Munck, Hideaki Mizuno, Wim Annaert
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-07-01
Series:eLife
Subjects:
Alzheimer's disease
gamma-secretase
presenilin1
super-resolution microscopy
single-particle tracking
Online Access:https://elifesciences.org/articles/56679

Internet

https://elifesciences.org/articles/56679

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