PKCtheta and HIV-1 transcriptional regulator Tat co-exist at the LTR promoter in CD4+ T cells

PKCtheta and HIV-1 transcriptional regulator Tat co-exist at the LTR promoter in CD4+ T cells

PKCtheta is essential for the activation of CD4+ T cells. Upon TCR/CD28 stimulation, PKCtheta is phosphorylated and migrates to the immunological synapse, inducing the activation of cellular transcription factors such as NF-kB and kinases as ERK that are critical for HIV-1 replication. We previously...

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Bibliographic Details
Main Authors: Maria Rosa eLopez-Huertas, Jasmine eLi, Anjum eZafar, Sara eRodriguez-Mora, Carlota eGarcía-Domínguez, Elena eMateos, Jose eAlcami, Sudha eRao, Mayte eCoiras
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Immunology
Subjects:
NF-kappa B
Protein kinase C theta
Ras/Raf/MEK/Erk pathway
HIV-1 Tat regulator
Nuclear colocalization
CD4+ T cell activation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00069/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00069/full

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