Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation

Liver failure: A NEAT possibility for treatment A long noncoding RNA molecule, one that does not encode the synthesis of protein, is implicated in acute liver failure (AHF) and might offer a new target for drugs to treat the condition. AHF can be induced by various factors, including viruses, drugs,...

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Main Authors:	Qiang Wang, Lian Liu, Sheng Zhang, Yingzi Ming, Shu Liu, Ke Cheng, Yujun Zhao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-03-01
Series:	Experimental and Molecular Medicine
Online Access:	https://doi.org/10.1038/s12276-020-0387-z

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spelling	doaj-a662a7316e9f4a55bf434640745043792021-03-11T12:47:07ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132020-03-0152346147210.1038/s12276-020-0387-zLong noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylationQiang Wang0Lian Liu1Sheng Zhang2Yingzi Ming3Shu Liu4Ke Cheng5Yujun Zhao6Transplantation Center, the Third Xiangya Hospital of Central South UniversityTransplantation Center, the Third Xiangya Hospital of Central South UniversityTransplantation Center, the Third Xiangya Hospital of Central South UniversityTransplantation Center, the Third Xiangya Hospital of Central South UniversityTransplantation Center, the Third Xiangya Hospital of Central South UniversityTransplantation Center, the Third Xiangya Hospital of Central South UniversityTransplantation Center, the Third Xiangya Hospital of Central South UniversityLiver failure: A NEAT possibility for treatment A long noncoding RNA molecule, one that does not encode the synthesis of protein, is implicated in acute liver failure (AHF) and might offer a new target for drugs to treat the condition. AHF can be induced by various factors, including viruses, drugs, alcohol abuse, and inherited traits. Ke Cheng, Yujun Zhao and colleagues at Central South University in Changsha, China investigated the role of this RNA, called NEAT1, in cell and animal models of AHF. They identified increased production of NEAT1, which suppressed liver cell proliferation and promoted liver cell death. They also uncovered molecular details of the mechanisms underlying these effects, in which the RNA altered the production and regulatory modification of certain proteins. Further research should investigate the therapeutic possibilities of interfering with NEAT1 activity.https://doi.org/10.1038/s12276-020-0387-z
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Qiang Wang Lian Liu Sheng Zhang Yingzi Ming Shu Liu Ke Cheng Yujun Zhao
spellingShingle	Qiang Wang Lian Liu Sheng Zhang Yingzi Ming Shu Liu Ke Cheng Yujun Zhao Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation Experimental and Molecular Medicine
author_facet	Qiang Wang Lian Liu Sheng Zhang Yingzi Ming Shu Liu Ke Cheng Yujun Zhao
author_sort	Qiang Wang
title	Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation
title_short	Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation
title_full	Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation
title_fullStr	Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation
title_full_unstemmed	Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation
title_sort	long noncoding rna neat1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of ezh2 to the lats2 promoter region and promotion of h3k27me3 methylation
publisher	Nature Publishing Group
series	Experimental and Molecular Medicine
issn	1226-3613 2092-6413
publishDate	2020-03-01
description	Liver failure: A NEAT possibility for treatment A long noncoding RNA molecule, one that does not encode the synthesis of protein, is implicated in acute liver failure (AHF) and might offer a new target for drugs to treat the condition. AHF can be induced by various factors, including viruses, drugs, alcohol abuse, and inherited traits. Ke Cheng, Yujun Zhao and colleagues at Central South University in Changsha, China investigated the role of this RNA, called NEAT1, in cell and animal models of AHF. They identified increased production of NEAT1, which suppressed liver cell proliferation and promoted liver cell death. They also uncovered molecular details of the mechanisms underlying these effects, in which the RNA altered the production and regulatory modification of certain proteins. Further research should investigate the therapeutic possibilities of interfering with NEAT1 activity.
url	https://doi.org/10.1038/s12276-020-0387-z
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Long noncoding RNA NEAT1 suppresses hepatocyte proliferation in fulminant hepatic failure through increased recruitment of EZH2 to the LATS2 promoter region and promotion of H3K27me3 methylation

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