Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5

Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor5

Tumor-associated blood vessels and lymphatics are abnormal and dysfunctional. These are hallmarks of the tumor microenvironment, which has an immunosuppressive nature, such as through hypoxia. Treatment with anti-death receptor5 (DR5) monoclonal antibody MD5-1, which induces tumor cell death, is a p...

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Bibliographic Details
Main Authors: Yoko Tsukita, Tatsuma Okazaki, Satoru Ebihara, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Taizou Hirano, Hisatoshi Sugiura, Tsutomu Tamada, Nobuyuki Tanaka, Yasufumi Sato, Hideo Yagita, Masakazu Ichinose
Format: Article
Language:English
Published: Taylor & Francis Group 2019-02-01
Series:OncoImmunology
Subjects:
death receptor5
immunotherapy
lymphatics
blood vessels
tumor microenvironment
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1543526

Internet

http://dx.doi.org/10.1080/2162402X.2018.1543526

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