Dynamic changes of the normal B lymphocyte repertoire in CLL in response to ibrutinib or FCR chemo-immunotherapy

Dynamic changes of the normal B lymphocyte repertoire in CLL in response to ibrutinib or FCR chemo-immunotherapy

Using next-generation immunoglobulin (IGH) sequencing and flow cytometry, we characterized the composition, diversity and dynamics of non-malignant B cells in patients undergoing treatment with the Bruton tyrosine kinase (BTK) inhibitor ibrutinib or chemo-immunotherapy with fludarabine, cyclophospha...

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Bibliographic Details
Main Authors: Simon Schliffke, Mariela Sivina, Ekaterina Kim, Lisa von Wenserski, Benjamin Thiele, Nuray Akyüz, Clemens Falker-Gieske, Donjete Statovci, Anna Oberle, Toni Thenhausen, Artus Krohn-Grimberghe, Carsten Bokemeyer, Nitin Jain, Zeev Estrov, Alessandra Ferrajoli, William Wierda, Michael Keating, Jan A. Burger, Mascha Binder
Format: Article
Language:English
Published: Taylor & Francis Group 2018-04-01
Series:OncoImmunology
Subjects:
ibrutinib
chronic lymphocytic leukemia
b lymphocyte repertoire
chemo-immunotherapy
immunomonitoring
Online Access:http://dx.doi.org/10.1080/2162402X.2017.1417720

Internet

http://dx.doi.org/10.1080/2162402X.2017.1417720

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