Impact of circulating cholesterol levels on growth and intratumoral androgen concentration of prostate tumors.

Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence of gonadal androgens, termed castration resistant PCa (CRPC). Theories underly...

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Bibliographic Details
Main Authors: Elahe A Mostaghel, Keith R Solomon, Kristine Pelton, Michael R Freeman, R Bruce Montgomery
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3261168?pdf=render