Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth

Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth

Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked to an increased risk of melanoma. Here, we have examined the potential connection between cGMP-dependent signaling cascades and melanoma growth. Using a combination of bioch...

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Bibliographic Details
Main Authors: Sandeep Dhayade, Susanne Kaesler, Tobias Sinnberg, Hyazinth Dobrowinski, Stefanie Peters, Ulrike Naumann, He Liu, Robert E. Hunger, Martin Thunemann, Tilo Biedermann, Birgit Schittek, Hans-Uwe Simon, Susanne Feil, Robert Feil
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301310

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http://www.sciencedirect.com/science/article/pii/S2211124716301310

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