T cell--associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model

T cell--associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model

Although oxymatrine (OMT) has been shown to directly inhibit the replication of hepatitis B virus (HBV) in vitro, limited research has been done with this drug in vivo. In the present study, the antiviral effect of OMT was investigated in an immunocompetent mouse model of chronic HBV infection. The...

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Bibliographic Details
Main Authors: Xiuxiu Sang, Ruilin Wang, Yanzhong Han, Cong'en Zhang, Honghui Shen, Zhirui Yang, Yin Xiong, Huimin Liu, Shijing Liu, Ruisheng Li, Ruichuang Yang, Jiabo Wang, Xuejun Wang, Zhaofang Bai, Xiaohe Xiao
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
HBV
Oxymatrine
CD4+ T cell
IFN-γ
Mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383517300710

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http://www.sciencedirect.com/science/article/pii/S2211383517300710

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