Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation

Denervation of muscle fibres induces muscle atrophy, via mechanisms that remain unclear. Here, the authors show that binding of acetylcoline to its receptor at the neuromuscular junction represses the expression of connexins 43 and 45, which promote atrophy, and is sufficient to prevent denervation-...

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Bibliographic Details
Main Authors: Bruno A. Cisterna, Aníbal A. Vargas, Carlos Puebla, Paola Fernández, Rosalba Escamilla, Carlos F. Lagos, María F. Matus, Cristian Vilos, Luis A. Cea, Esteban Barnafi, Hugo Gaete, Daniel F. Escobar, Christopher P. Cardozo, Juan C. Sáez
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-14063-8

Internet

https://doi.org/10.1038/s41467-019-14063-8

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