Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases

Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases

DNA replication licensing occurs on chromatin, but how the chromatin template is regulated for replication remains mostly unclear. Here, we have analyzed the requirement of histone methyltransferases for a specific type of replication: the DNA re-replication induced by the downregulation of either G...

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Bibliographic Details
Main Authors: Fei Lu, Xiaojun Wu, Feng Yin, Christina Chia-Fang Lee, Min Yu, Ivailo S. Mihaylov, Jiekai Yu, Hong Sun, Hui Zhang
Format: Article
Language:English
Published: The Company of Biologists 2016-10-01
Series:Biology Open
Subjects:
DNA replication
H3K4 methylation
WDR5
RBBP5
Re-replication
Online Access:http://bio.biologists.org/content/5/10/1449

Internet

http://bio.biologists.org/content/5/10/1449

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