Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells

Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells

Reversine is a potent antitumor 2,6-diamino-substituted purine acting as an Aurora kinases inhibitor and interfering with cancer cell cycle progression. In this study we describe three reversine-related molecules, designed by docking calculation, that present structural modifications in the diamino...

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Bibliographic Details
Main Authors: Bartolomeo Bosco, Andrea Defant, Andrea Messina, Tania Incitti, Denise Sighel, Angela Bozza, Yari Ciribilli, Alberto Inga, Simona Casarosa, Ines Mancini
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Molecules
Subjects:
reversine
microwave-assisted synthesis
molecular docking
cell cycle arrest
endoreduplication
p53
Online Access:http://www.mdpi.com/1420-3049/23/8/1996

Internet

http://www.mdpi.com/1420-3049/23/8/1996

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