Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila

Manipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila

Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe cognitive deterioration. While causes of AD pathology are debated, a large body of evidence suggests that increased cleavage of Amyloid Precursor Protein (APP) producing the neurotoxic Amyloid-β (Aβ) peptide plays a...

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Bibliographic Details
Main Authors: Matthew R. Blake, Scott D. Holbrook, Joanna Kotwica-Rolinska, Eileen S. Chow, Doris Kretzschmar, Jadwiga M. Giebultowicz
Format: Article
Language:English
Published: Elsevier 2015-05-01
Series:Neurobiology of Disease
Subjects:
Circadian rhythms
period gene
Amyloid precursor protein
Amyloid intracellular domain
BACE
Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611500039X

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http://www.sciencedirect.com/science/article/pii/S096999611500039X

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