Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

Evaluation of the Adverse Effects of Chronic Exposure to Donepezil (An Acetylcholinesterase Inhibitor) in Adult Zebrafish by Behavioral and Biochemical Assessments

Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including causing abnormal cardiac rhythm, insomnia, vomiting, and muscle cramps. However, the existence of these effects in subj...

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Bibliographic Details
Main Authors: Gilbert Audira, Nguyen Thi Ngoc Anh, Bui Thi Ngoc Hieu, Nemi Malhotra, Petrus Siregar, Omar Villalobos, Oliver B. Villaflores, Tzong-Rong Ger, Jong-Chin Huang, Kelvin H.-C. Chen, Chung-Der Hsiao
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
donepezil
acetylcholinesterase inhibitor
dementia
zebrafish
behavior
Online Access:https://www.mdpi.com/2218-273X/10/9/1340

Internet

https://www.mdpi.com/2218-273X/10/9/1340

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