Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Tracking of epigenetic changes during hematopoietic differentiation of induced pluripotent stem cells

Abstract Background Differentiation of induced pluripotent stem cells (iPSCs) toward hematopoietic progenitor cells (HPCs) raises high hopes for disease modeling, drug screening, and cellular therapy. Various differentiation protocols have been established to generate iPSC-derived HPCs (iHPCs) that...

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Bibliographic Details
Main Authors: Olivia Cypris, Joana Frobel, Shivam Rai, Julia Franzen, Stephanie Sontag, Roman Goetzke, Marcelo A. Szymanski de Toledo, Martin Zenke, Wolfgang Wagner
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
Epigenetic
Hematopoiesis
Induced pluripotent stem cells
Mesenchymal stromal cells
Stromal support
Online Access:http://link.springer.com/article/10.1186/s13148-019-0617-1

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http://link.springer.com/article/10.1186/s13148-019-0617-1

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