Formulation in DDA-MPLA-TDB Liposome Enhances the Immunogenicity and Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection

Formulation in DDA-MPLA-TDB Liposome Enhances the Immunogenicity and Protective Efficacy of a DNA Vaccine against Mycobacterium tuberculosis Infection

Despite the vaccine Mycobacterium bovis Bacillus Calmette–Guérin is used worldwide, tuberculosis (TB) remains the first killer among infectious diseases. An effective vaccine is urgently required. DNA vaccine has shown prophylactic as well as therapeutic effects against TB, while its weak immunogeni...

Full description

Bibliographic Details
Main Authors: Maopeng Tian, Zijie Zhou, Songwei Tan, Xionglin Fan, Longmeng Li, Nadeem Ullah
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
dimethyldioctadecylammonium
trehalose 6,6′-dibehenate
monophosphoryl lipid A
liposome
adjuvant
DNA vaccine
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00310/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00310/full

Similar Items