Influence of proton pump inhibitors on blood dabigatran concentrations in Japanese patients with non-valvular atrial fibrillation

Influence of proton pump inhibitors on blood dabigatran concentrations in Japanese patients with non-valvular atrial fibrillation

Background: Dabigatran is a direct thrombin inhibitor used to decrease the risk of ischemic stroke in patients with non-valvular atrial fibrillation (NVAF). Its prodrug, dabigatran etexilate (DE) is often co-administrated with a proton pump inhibitor (PPI) because of its adverse effects on the gastr...

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Bibliographic Details
Main Authors: Tasuku Kuwayama, MD, Hiroyuki Osanai, MD, Masayoshi Ajioka, MD, Kotaro Tokuda, MD, Hirofumi Ohashi, MD, Akihiro Tobe, MD, Tatsuya Yoshida, MD, Tomohiro Masutomi, MD, Takahiro Kambara, MD, Yosuke Inoue, MD, Yoshihito Nakashima, MD, Hiroshi Asano, MD, Kazuyoshi Sakai, MD
Format: Article
Language:English
Published: Wiley 2017-12-01
Series:Journal of Arrhythmia
Online Access:http://www.sciencedirect.com/science/article/pii/S1880427617301400

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http://www.sciencedirect.com/science/article/pii/S1880427617301400

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