Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention

Targeting the Urokinase-Type Plasminogen Activator Receptor (uPAR) in Human Diseases With a View to Non-invasive Imaging and Therapeutic Intervention

The interaction between the serine protease urokinase-type plasminogen activator (uPA) and its glycolipid-anchored receptor (uPAR) focalizes plasminogen activation to cell surfaces, thereby regulating extravascular fibrinolysis, cell adhesion, and migration. uPAR belongs to the Ly6/uPAR (LU) gene su...

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Bibliographic Details
Main Authors: Julie Maja Leth, Michael Ploug
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
PET imaging
fluorescence guided surgery
LU domain
uPAR
optical imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.732015/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.732015/full

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