Metformin enhances erectile function in rats with aging-induced erectile dysfunction by activating AMPK/mTOR pathway-regulated autophagy in corpus cavernosum

Metformin enhances erectile function in rats with aging-induced erectile dysfunction by activating AMPK/mTOR pathway-regulated autophagy in corpus cavernosum

Objective To investigate the effect of metformin on erectile function and its regulation on cavernous fibrosis and autophagy in aged rats, and explore the underlying mechanism. Methods Forty healthy 2-month-old male SD rats were randomly divided into groups A, B, C and D. APO at a dose of 100 mg/kg...

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Bibliographic Details
Main Authors: DING Fan, LI Hongwei, OUYANG Qin, WU Xiaojun
Format: Article
Language:zho
Published: Editorial Office of Journal of Third Military Medical University 2020-06-01
Series:Di-san junyi daxue xuebao
Subjects:
erectile dysfunction
metformin
autophagy
ampk
mtor
Online Access:http://aammt.tmmu.edu.cn/Upload/rhtml/201912208.htm

Internet

http://aammt.tmmu.edu.cn/Upload/rhtml/201912208.htm

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