hR3 modification with DOTA-NHS. 90Y labeling and biodistribution

The conjugation, characterization and biodistribution of -DOTA-hR3 radioimmunoconjugate are reported in this work. DOTA was used as bifunctional chelating agent. Molar ratios 320:1, 160:1 and 88:1 DOTA/monoclonal antibody hR3 were studied in order to evaluate their influence on the integrity of conj...

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Bibliographic Details
Main Authors: Dianelys Ondarse Álvarez, Rene Leyva Montaña, Minely Zamora Barrabí
Format: Article
Language:English
Published: Centro de Gestión de la Información y Desarrollo de la Energía (CUBAENERGIA) 2011-01-01
Series:Nucleus
Subjects:
Online Access:http://nucleus.cubaenergia.cu/index.php/nucleus/article/view/547