In Situ Gelling Systems Using Pluronic F127 Enhance Corneal Permeability of Indomethacin Nanocrystals

In Situ Gelling Systems Using Pluronic F127 Enhance Corneal Permeability of Indomethacin Nanocrystals

We previously designed an ophthalmic dispersion containing indomethacin nanocrystals (IMC-NCs), showing that multiple energy-dependent endocytoses led to the enhanced absorption of drugs from ocular dosage forms. In this study, we attempted to prepare Pluronic F-127 (PLF-127)-based in situ gel (ISG)...

Full description

Bibliographic Details
Main Authors: Noriaki Nagai, Takumi Isaka, Saori Deguchi, Misa Minami, Mizuki Yamaguchi, Hiroko Otake, Norio Okamoto, Yosuke Nakazawa
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
nanoparticles
indomethacin
Pluronic F-127
in situ gelling system
ophthalmic delivery system
Online Access:https://www.mdpi.com/1422-0067/21/19/7083

Internet

https://www.mdpi.com/1422-0067/21/19/7083

Similar Items