Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

Impact of LEDGIN treatment during virus production on residual HIV-1 transcription

Abstract Background Persistence of latent, replication-competent provirus is the main impediment towards the cure of HIV infection. One of the critical questions concerning HIV latency is the role of integration site selection in HIV expression. Inhibition of the interaction between HIV integrase an...

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Bibliographic Details
Main Authors: Gerlinde Vansant, Lenard S. Vranckx, Irena Zurnic, Dominique Van Looveren, Paulien Van de Velde, Christopher Nobles, Rik Gijsbers, Frauke Christ, Zeger Debyser
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Retrovirology
Subjects:
HIV latency
Integrase
LEDGF/p75
LEDGINs
Online Access:http://link.springer.com/article/10.1186/s12977-019-0472-3

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http://link.springer.com/article/10.1186/s12977-019-0472-3

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