Angiopoietin-Like 3 Induces Podocyte F-Actin Rearrangement through Integrin αVβ3/FAK/PI3K Pathway-Mediated Rac1 Activation
Glomerular podocytes are highly differentiated cells whose foot processes, which are mainly maintained by the architecture of actin filaments, have a unique morphology. A rearrangement of F-actin in podocytes causes changes in their motility that involve foot process effacement and proteinuria in gl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2013-01-01
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| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2013/135608 |