Autism Spectrum Disorder Risk Factor Met Regulates the Organization of Inhibitory Synapses

A common hypothesis explains autism spectrum disorder (ASD) as a neurodevelopmental disorder linked to excitatory/inhibitory (E/I) imbalance in neuronal network connectivity. Mutation of genes including Met and downstream signaling components, e.g., PTEN, Tsc2 and, Rheb are involved in the control o...

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Bibliographic Details
Main Authors: Pauline Jeckel, Martin Kriebel, Hansjürgen Volkmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2021.659856/full