Cell Factory Design and Culture Process Optimization for Dehydroshikimate Biosynthesis in Escherichia coli

3-Dehydroshikimate (DHS) is a useful starting metabolite for the biosynthesis of muconic acid (MA) and shikimic acid (SA), which are precursors of various valuable polymers and drugs. Although DHS biosynthesis has been previously reported in several bacteria, the engineered strains were far from sat...

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Main Authors: Si-Sun Choi, Seung-Yeul Seo, Sun-Ok Park, Han-Na Lee, Ji-soo Song, Ji-yeon Kim, Ji-Hoon Park, Sangyong Kim, Sang Joung Lee, Gie-Taek Chun, Eung-Soo Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fbioe.2019.00241/full