Comprehensive DNA Adduct Analysis Reveals Pulmonary Inflammatory Response Contributes to Genotoxic Action of Magnetite Nanoparticles

Comprehensive DNA Adduct Analysis Reveals Pulmonary Inflammatory Response Contributes to Genotoxic Action of Magnetite Nanoparticles

Nanosized-magnetite (MGT) is widely utilized in medicinal and industrial fields; however, its toxicological properties are not well documented. In our previous report, MGT showed genotoxicity in both in vitro and in vivo assay systems, and it was suggested that inflammatory responses exist behind th...

Full description

Bibliographic Details
Main Authors: Kousuke Ishino, Tatsuya Kato, Mamoru Kato, Tatsuhiro Shibata, Masatoshi Watanabe, Keiji Wakabayashi, Hitoshi Nakagama, Yukari Totsuka
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:International Journal of Molecular Sciences
Subjects:
magnetite nanoparticle
pulmonary inflammation
intratracheal instillation
DNA adductome
Online Access:http://www.mdpi.com/1422-0067/16/2/3474

Internet

http://www.mdpi.com/1422-0067/16/2/3474

Similar Items