A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice

A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice

The benzoazepinoqunolinone derivative, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), which is produced in a mixture of glucose and tryptophan incubated at 37 °C under physiological conditions in the presence or absence of hydroxyl radicals caused by the Fenton reaction, is a...

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Bibliographic Details
Main Authors: Takahiro Kochi, Masahito Shimizu, Yukari Totsuka, Yohei Shirakami, Takayuki Nakanishi, Tetsushi Watanabe, Takuji Tanaka, Hitoshi Nakagama, Keiji Wakabayashi, Hisataka Moriwaki
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Benzoazepinoqunolinone
Heterocyclic amines
Maillard reaction
Fenton reaction
High-grade dysplasia
PDCD4
Colon
Dextran sodium sulfate
Initiation
Mice
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014000183

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http://www.sciencedirect.com/science/article/pii/S2214750014000183

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