The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.

Bibliographic Details
Main Authors: Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10321-x
id doaj-a5ac163b4ca344899aba6fd306311cef
record_format Article
spelling doaj-a5ac163b4ca344899aba6fd306311cef2021-05-11T12:21:48ZengNature Publishing GroupNature Communications2041-17232019-06-0110111410.1038/s41467-019-10321-xThe ORC ubiquitin ligase OBI1 promotes DNA replication origin firingPhilippe Coulombe0Joelle Nassar1Isabelle Peiffer2Slavica Stanojcic3Yvon Sterkers4Axel Delamarre5Stéphane Bocquet6Marcel Méchali7Institute of Human Genetics, UMR 9002, CNRS-Université de MontpellierInstitute of Human Genetics, UMR 9002, CNRS-Université de MontpellierInstitute of Human Genetics, UMR 9002, CNRS-Université de MontpellierCNRS 5290 - IRD 224 - University of Montpellier (UMR “MiVEGEC”)CNRS 5290 - IRD 224 - University of Montpellier (UMR “MiVEGEC”)Institute of Human Genetics, UMR 9002, CNRS-Université de MontpellierInstitute of Human Genetics, UMR 9002, CNRS-Université de MontpellierInstitute of Human Genetics, UMR 9002, CNRS-Université de MontpellierDNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.https://doi.org/10.1038/s41467-019-10321-x
collection DOAJ
language English
format Article
sources DOAJ
author Philippe Coulombe
Joelle Nassar
Isabelle Peiffer
Slavica Stanojcic
Yvon Sterkers
Axel Delamarre
Stéphane Bocquet
Marcel Méchali
spellingShingle Philippe Coulombe
Joelle Nassar
Isabelle Peiffer
Slavica Stanojcic
Yvon Sterkers
Axel Delamarre
Stéphane Bocquet
Marcel Méchali
The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
Nature Communications
author_facet Philippe Coulombe
Joelle Nassar
Isabelle Peiffer
Slavica Stanojcic
Yvon Sterkers
Axel Delamarre
Stéphane Bocquet
Marcel Méchali
author_sort Philippe Coulombe
title The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_short The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_full The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_fullStr The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_full_unstemmed The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing
title_sort orc ubiquitin ligase obi1 promotes dna replication origin firing
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.
url https://doi.org/10.1038/s41467-019-10321-x
work_keys_str_mv AT philippecoulombe theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT joellenassar theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT isabellepeiffer theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT slavicastanojcic theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT yvonsterkers theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT axeldelamarre theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT stephanebocquet theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT marcelmechali theorcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT philippecoulombe orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT joellenassar orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT isabellepeiffer orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT slavicastanojcic orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT yvonsterkers orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT axeldelamarre orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT stephanebocquet orcubiquitinligaseobi1promotesdnareplicationoriginfiring
AT marcelmechali orcubiquitinligaseobi1promotesdnareplicationoriginfiring
_version_ 1721444955397816320

Similar Items