The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

The ORC ubiquitin ligase OBI1 promotes DNA replication origin firing

DNA replication is initiated at defined genomic sites called origins of replication following ORC pre-replicative complex assembly. Here the authors identify a protein ubiquitylating ORC that is involved in origin activation and may act as a selector of origins to be fired.

Bibliographic Details
Main Authors: Philippe Coulombe, Joelle Nassar, Isabelle Peiffer, Slavica Stanojcic, Yvon Sterkers, Axel Delamarre, Stéphane Bocquet, Marcel Méchali
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10321-x

Internet

https://doi.org/10.1038/s41467-019-10321-x

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