Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model

Exploring the Role of Osteosarcoma-Derived Extracellular Vesicles in Pre-Metastatic Niche Formation and Metastasis in the 143-B Xenograft Mouse Osteosarcoma Model

The pre-metastatic niche (PMN) is a tumor-driven microenvironment in distant organs that can foster and support the survival and growth of disseminated tumor cells. This facilitates the establishment of secondary lesions that eventually form overt metastasis, the main cause of cancer-related death....

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Bibliographic Details
Main Authors: Alekhya Mazumdar, Joaquin Urdinez, Aleksandar Boro, Matthias J. E. Arlt, Fabian E. Egli, Barbara Niederöst, Patrick K. Jaeger, Greta Moschini, Roman Muff, Bruno Fuchs, Jess G. Snedeker, Ana Gvozdenovic
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
osteosarcoma
premetastatic niche
extracellular vesicles
myeloid cell infiltration
Online Access:https://www.mdpi.com/2072-6694/12/11/3457

Internet

https://www.mdpi.com/2072-6694/12/11/3457

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