Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

Identification of PARP-7 substrates reveals a role for MARylation in microtubule control in ovarian cancer cells

PARP-7 (TiPARP) is a mono(ADP-ribosyl) transferase whose protein substrates and biological activities are poorly understood. We observed that PARP7 mRNA levels are lower in ovarian cancer patient samples compared to non-cancerous tissue, but PARP-7 protein nonetheless contributes to several cancer-r...

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Bibliographic Details
Main Authors: Lavanya H Palavalli Parsons, Sridevi Challa, Bryan A Gibson, Tulip Nandu, MiKayla S Stokes, Dan Huang, Jayanthi S Lea, W Lee Kraus
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
adp-ribosylation
PARP-7
ovarian cancer
chemical genetics
alpha-tubulin
transcriptome
Online Access:https://elifesciences.org/articles/60481

Internet

https://elifesciences.org/articles/60481

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