Identification of 6-(piperazin-1-yl)-1,3,5-triazine as a chemical scaffold with broad anti-schistosomal activities [version 1; peer review: 1 approved, 2 approved with reservations]

Background: Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease of considerable importance in resource-poor communities throughout the developing world. In the absence of an immunoprophylactic vaccine and due to over-reliance on a single chemotherapy (...

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Bibliographic Details
Main Authors: Gilda Padalino, Iain W. Chalmers, Andrea Brancale, Karl F. Hoffmann
Format: Article
Language:English
Published: Wellcome 2020-07-01
Series:Wellcome Open Research
Online Access:https://wellcomeopenresearch.org/articles/5-169/v1