Reversal of Hypoxic Pulmonary Hypertension by Hypoxia-Inducible Overexpression of Angiotensin-(1-7) in Pulmonary Endothelial Cells

Reversal of Hypoxic Pulmonary Hypertension by Hypoxia-Inducible Overexpression of Angiotensin-(1-7) in Pulmonary Endothelial Cells

Hypoxia-induced pulmonary vascular constriction and structure remodeling are the main causes of hypoxic pulmonary hypertension. In the present study, an adeno-associated virus vector, containing Tie2 promoter and hypoxia response elements, was designed and named HTSFcAng(1-7). Its targeting, hypoxic...

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Bibliographic Details
Main Authors: Man-Ling Liu, Shu-Juan Xing, Xiao-Qing Liang, Ying Luo, Bo Zhang, Zhi-Chao Li, Ming-Qing Dong
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
pulmonary hypertension
hypobaric hypoxia
adeno-associated virus vector
gene therapy
angiotensin-(1-7)
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300681

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http://www.sciencedirect.com/science/article/pii/S2329050120300681

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