SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.

SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.

Chronic inflammation is a major contributing factor in the pathogenesis of many age-associated diseases. One central protein that regulates inflammation is NF-κB, the activity of which is modulated by post-translational modifications as well as by association with co-activator and co-repressor prote...

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Bibliographic Details
Main Authors: Hongying Yang, Wei Zhang, Heng Pan, Heidi G Feldser, Elden Lainez, Christine Miller, Stewart Leung, Zhong Zhong, Huizhen Zhao, Sharon Sweitzer, Thomas Considine, Thomas Riera, Vipin Suri, Brian White, James L Ellis, George P Vlasuk, Christine Loh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3460821?pdf=render

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http://europepmc.org/articles/PMC3460821?pdf=render

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