AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke

AAV-mediated netrin-1 overexpression increases peri-infarct blood vessel density and improves motor function recovery after experimental stroke

Apart from its role in axon guidance, netrin-1 is also known to be pro-angiogenic. The aim of this study is to determine whether adeno-associated viral (AAV) mediated overexpression of netrin-1 improves post-stroke neurovascular structure and recovery of function. AAV-Netrin-1 or AAV-LacZ of 1×1010...

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Bibliographic Details
Main Authors: Hui Sun, Thang Le, Tiffany T.J. Chang, Aisha Habib, Steven Wu, Fanxia Shen, William L. Young, Hua Su, Jialing Liu
Format: Article
Language:English
Published: Elsevier 2011-10-01
Series:Neurobiology of Disease
Subjects:
Forelimb asymmetry
Distal MCA occlusion
Barnes maze
Microvessel density
Doublecortin
Angiogenesis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611100204X

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http://www.sciencedirect.com/science/article/pii/S096999611100204X

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