Pretomanid dose selection for pulmonary tuberculosis: An application of multi‐objective optimization to dosage regimen design
Abstract Clinical development of combination chemotherapies for tuberculosis (TB) is complicated by partial or restricted phase II dose‐finding. Barriers include a propensity for drug resistance with monotherapy, practical limits on numbers of treatment arms for component dose combinations, and limi...
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| Format: | Article |
| Language: | English |
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Wiley
2021-03-01
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| Series: | CPT: Pharmacometrics & Systems Pharmacology |
| Online Access: | https://doi.org/10.1002/psp4.12591 |