De novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types

De novo missense variants disrupting protein–protein interactions affect risk for autism through gene co-expression and protein networks in neuronal cell types

Abstract Background Whole-exome sequencing studies have been useful for identifying genes that, when mutated, affect risk for autism spectrum disorder (ASD). Nonetheless, the association signal primarily arises from de novo protein-truncating variants, as opposed to the more common missense variants...

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Bibliographic Details
Main Authors: Siwei Chen, Jiebiao Wang, Ercument Cicek, Kathryn Roeder, Haiyuan Yu, Bernie Devlin
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Molecular Autism
Subjects:
Autism spectrum disorder
De novo missense variation
Protein–protein interaction
Cell-type-specific transcriptome
Online Access:http://link.springer.com/article/10.1186/s13229-020-00386-7

Internet

http://link.springer.com/article/10.1186/s13229-020-00386-7

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