Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

Notch4 activation aggravates NF-κB-mediated inflammation in HIV-1-associated nephropathy

Notch pathway activation plays a central role in the pathogenesis of many glomerular diseases. We have previously shown that Notch4 expression was upregulated in various renal cells in human immunodeficiency virus (HIV)-associated nephropathy (HIVAN) patients and rodent models of HIVAN. In this stud...

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Bibliographic Details
Main Authors: Rajni Vaid Puri, Sireesha Yerrathota, Trisha Home, Jessica Y. Idowu, V. Praveen Chakravarthi, Christopher J. Ward, Pravin C. Singhal, Gregory B. Vanden Heuvel, Timothy A. Fields, Madhulika Sharma
Format: Article
Language:English
Published: The Company of Biologists 2019-12-01
Series:Disease Models & Mechanisms
Subjects:
hivan
notch4
inflammation
Online Access:http://dmm.biologists.org/content/12/12/dmm040642

Internet

http://dmm.biologists.org/content/12/12/dmm040642

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