Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design. Here, we use a systematically designed series of multi-domain constructs in combina...

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Bibliographic Details
Main Authors: Ching-Lin Hsieh, Christopher P Ptak, Andrew Tseng, Igor Massahiro de Souza Suguiura, Sean P McDonough, Tepyuda Sritrakul, Ting Li, Yi-Pin Lin, Richard E Gillilan, Robert E Oswald, Yung-Fu Chang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-12-01
Series:eLife
Subjects:
LigB structure
mAb accessibility
vaccine design
Online Access:https://elifesciences.org/articles/30051

Internet

https://elifesciences.org/articles/30051

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