Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor

Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor

Cyclotides are plant derived, cystine-knot stabilized peptides characterized by their natural abundance, sequence variability and structural plasticity. They are abundantly expressed in Rubiaceae, Psychotrieae in particular. Previously the cyclotide kalata B7 was identified to modulate the human oxy...

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Bibliographic Details
Main Authors: Mohsen Fahradpour, Peter Keov, Carlotta Tognola, Estela Perez-Santamarina, Peter J. McCormick, Alireza Ghassempour, Christian W. Gruber
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Pharmacology
Subjects:
plant peptides
circular peptide
pharmacognosy
ipecac
GPCR
corticotropin-releasing factor
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00616/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00616/full

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