DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

DNA topoisomerase IIβ stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression

Abstract Background DNA topoisomerase IIβ (topo IIβ) is known to regulate neural differentiation by inducing the neuronal genes responsible for critical neural differentiation events such as neurite outgrowth and axon guidance. However, the pathways of axon growth controlled by topo IIβ have not bee...

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Bibliographic Details
Main Authors: Merve Zaim, Sevim Isik
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Stem Cell Research & Therapy
Subjects:
Human mesenchymal stem cells
Neural differentiation
Neurite outgrowth
DNA topoisomerase IIβ
Rho GTPases
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13287-018-0859-4

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http://link.springer.com/article/10.1186/s13287-018-0859-4

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