Progesterone Negatively Regulates BCRP in Progesterone Receptor-Positive Human Breast Cancer Cells

Progesterone Negatively Regulates BCRP in Progesterone Receptor-Positive Human Breast Cancer Cells

Background/Aims: Breast cancer resistance protein (BCRP) plays a crucial role in multidrug resistance (MDR). Previous studies have shown that steroid hormones, like progesterone (PROG), regulate BCRP expression. The presence of a progesterone response element (PRE) in the BCRP promoter, suggests tha...

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Bibliographic Details
Main Authors: Xiaojuan Wu, Xiaofang Zhang, Limin Sun, Hui Zhang, Li Li, Xiao Wang, Weiwei Li, Peng Su, Jing Hu, Peng Gao, Gengyin Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
Transcriptional regulation
Progesterone
RU-486
Breast cancer cells
Breast cancer resistance protein
Online Access:http://www.karger.com/Article/FullText/354442

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http://www.karger.com/Article/FullText/354442

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