Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways

Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel Pathways

Traumatic brain injury (TBI) results in complex pathological reactions, where the initial lesion is followed by secondary inflammation and edema. Our laboratory and others have reported that angiotensin receptor blockers (ARBs) have efficacy in improving recovery from traumatic brain injury in mice....

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Bibliographic Details
Main Authors: Peter J. Attilio, Dustin M. Snapper, Milan Rusnak, Akira Isaac, Anthony R. Soltis, Matthew D. Wilkerson, Clifton L. Dalgard, Aviva J. Symes
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Neuroscience
Subjects:
traumatic brain injury
angiotensin
RNA seq
hippocampus
candesartan
transcriptomic (RNA-Seq)
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.636259/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.636259/full

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