Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress.

Intracellular pathogens must egress from the host cell to continue their infectious cycle. Apicomplexans are a phylum of intracellular protozoans that have evolved members of the membrane attack complex and perforin (MACPF) family of pore forming proteins to disrupt cellular membranes for traversing...

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Bibliographic Details
Main Authors: Alfredo J Guerra, Ou Zhang, Constance M E Bahr, My-Hang Huynh, James DelProposto, William C Brown, Zdzislaw Wawrzak, Nicole M Koropatkin, Vern B Carruthers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007476