Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome

Chronic myelomonocytic leukaemia stem cell transcriptomes anticipate disease morphology and outcome

Background: Chronic myelomonocytic leukaemia (CMML) is a clinically heterogeneous stem cell malignancy with overlapping features of myelodysplasia and myeloproliferation. Over 90% of patients carry mutations in epigenetic and/or splicing genes, typically detectable in the Lin−CD34+CD38− immunophenot...

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Bibliographic Details
Main Authors: Daniel H Wiseman, Syed M Baker, Arundhati V Dongre, Kristian Gurashi, Joanna A Storer, Tim CP Somervaille, Kiran Batta
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:EBioMedicine
Subjects:
CMML
Stem cells
sc-RNA Seq
Leukaemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420302796

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http://www.sciencedirect.com/science/article/pii/S2352396420302796

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