Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease

Mast Cells Are Mediators of Fibrosis and Effector Cell Recruitment in Dermal Chronic Graft-vs.-Host Disease

Allogeneic hematopoietic stem cell transplant (allo-HSCT) is often used to treat acute leukemia or defects of hematopoiesis. Its widespread use is hampered by graft-vs.-host disease (GVHD), which has high morbidity and mortality in both acute and chronic subtypes. Chronic GVHD (cGVHD) occurs most fr...

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Bibliographic Details
Main Authors: Ethan Strattan, Senthilnathan Palaniyandi, Reena Kumari, Jing Du, Natalya Hakim, Timothy Huang, Melissa V. Kesler, C. Darrell Jennings, Jamie L. Sturgill, Gerhard C. Hildebrandt
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
GVHD
fibrosis
mast cells
skin
transplant
immunity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02470/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02470/full

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