STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain

STIM1 activation is regulated by a 14 amino acid sequence adjacent to the CRAC activation domain

Oligomerization of the Ca<sup>2+ </sup>sensor, STIM1, in the endoplasmic reticulum (ER) membrane, caused by depletion of ER Ca<sup>2+</sup> stores, results in STIM1 coupling to the plasma membrane Ca<sup>2+ </sup>channel protein, Orai1, to activate Ca<sup>2+...

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Bibliographic Details
Main Authors: Marek K. Korzeniowski, Barbara Baird, David Holowka
Format: Article
Language:English
Published: AIMS Press 2016-02-01
Series:AIMS Biophysics
Subjects:
CRAC channel protein1 (ORAI1)
cell signaling
fluorescence resonance energy transfer (FRET)
membrane function
stromal interaction molecule 1 (STIM1)
endoplasmic reticulum (ER)
conformational change
Online Access:http://www.aimspress.com/biophysics/article/653/fulltext.html

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http://www.aimspress.com/biophysics/article/653/fulltext.html

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