DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age

DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age

We employed Illumina 450 K Infinium microarrays to profile DNA methylation (DNAm) in neuronal nuclei separated by fluorescence-activated sorting from the postmortem orbitofrontal cortex (OFC) of heroin users who died from heroin overdose (N = 37), suicide completers (N = 22) with no evidence of hero...

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Bibliographic Details
Main Authors: Alexey Kozlenkov, Andrew E. Jaffe, Alisa Timashpolsky, Pasha Apontes, Sergei Rudchenko, Mihaela Barbu, William Byne, Yasmin L. Hurd, Steve Horvath, Stella Dracheva
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Genes
Subjects:
DNA methylation
drug addiction
heroin
suicide
brain
neurons
human
Online Access:http://www.mdpi.com/2073-4425/8/6/152

Internet

http://www.mdpi.com/2073-4425/8/6/152

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