Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles

Rational design of a multi-valent human papillomavirus vaccine by capsomere-hybrid co-assembly of virus-like particles

An effective vaccine for human papillomavirus (HPV) needs to protect from several genotypes. Here, Wang et al. provide a strategy to produce single capsomere-hybrid virus-like particle (chVLP) composed of capsomers of different genotypes and show that a nona-type chVLP induces similar levels of neut...

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Bibliographic Details
Main Authors: Daning Wang, Xinlin Liu, Minxi Wei, Ciying Qian, Shuo Song, Jie Chen, Zhiping Wang, Qin Xu, Yurou Yang, Maozhou He, Xin Chi, Shiwen Huang, Tingting Li, Zhibo Kong, Qingbing Zheng, Hai Yu, Yingbin Wang, Qinjian Zhao, Jun Zhang, Ningshao Xia, Ying Gu, Shaowei Li
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16639-1

Internet

https://doi.org/10.1038/s41467-020-16639-1

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